ArticleTuberculosis

Rodolphe Mérieux Laboratory of Haiti

Efficacy of nitazoxanide against clinical isolates of Mycobacterium Tuberculosis

Shigyo K, Ocheretina O, Merveille YM, Johnson WD, Pape JW, Nathan CF, Fitzgerald DW

Antimicrob Agents Chemother. 2013 Mar 18. [Epub ahead of print]

Abstract:

Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 16 μg/mL. However, its efficacy against clinical isolates of Mtb has not been determined. We found that NTZ’s MIC against 50 clinical isolates ranged from 12-28 μg/mL with a median of 16 μg/mL and was unaffected by resistance to first or second line anti-tuberculosis drugs or a diversity of spoligotypes.

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