Rodolphe Mérieux Laboratory of Haiti

False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load

Ocheretina O, Byrt E, Mabou MM, Royal-Mardi G, Merveille YM, Rouzier V, Fitzgerald DW, Pape JW

Diagn Microbiol Infect Dis. 2016 Jan 15


We report investigation of 22 TB cases with positive Xpert MTB/RIF result for resistance to Rifampin and « Very Low » MTB detection level. Twelve cases were false positive without rpoB mutations, 2 were false-positives with a silent mutation in rpoB codon T508, and only 10 were true positives.

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