Research Activities
Infectiology
- Surveillance of rodent-borne diseases in Phnom-Penh: the surveillance will target zoonotic pathogens known to be borne by rodents and / or insectivores (e.g Leptospira spp., hantaviruses, Rickettsia typhi, Yersinia pestis, Streptobacillus moniliformis and encephalomyocarditis virus) (supported by DSO National laboratory of Singapore).
- Surveillance of water-borne pathogens in Cambodia water sources: pahtogens of interest includes Enterobacteriae, Salmonella typhi, Vibrio cholera, E.coli, Schigella spp., Hepatitis A and E viruses, norovirus, rotavirus, enterovirus, influenza A and B viruses. (supported by DSO National laboratory of Singapore).
- Surveillance of pathogens responsible for enteric outbreak among children: In developing country, diarrheal diseases remain an important cause of mortality among children. This project has been proposed to identify etiological agents behind outbreaks of enteric infections in Cambodian children (supported by DSO National laboratory of Singapore).
- Surveillance of acute lower respiratory infections in children at the Pediatric Hospital, Phnom Penh, Cambodia: This project has been proposed to identify etiological agents behind the outbreaks of acute lower respiratory infections (ALRIS) in Cambodian children (supported by DSO National laboratory of Singapore).
- Plasmodium mixed infections analysis by molecular biology methods among eight villages of Rattanakiri province, Cambodia: 1166 samples coming from a high malaria endemic area are characterized for Plasmodium species using a new molecular biology tools based on RFLP and dHPLC. (supported by Institut Pasteur du Cambodge).
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency identification in eight villages of Rattanakiri province, Cambodia: This project has been proposed to identify the most frequent G6PD mutation within eight villages belonging to ethnic group minorities (supported by Institut Pasteur du Cambodge).
Pharmacology
- PECAN (Pharmacologie Efavirenz Cambodia Nevirapine): Pharmacokinetic variability and genetic polymorphism of cytochrome P-450 in a HIV-infected Cambodian population and treated with nevirapine or efavirenz as part of their antiretroviral therapy (ANRS12154- Pecan).
Method and technology evaluation
- Comparison of three DNA extraction methods
- Setting up of a plasmatic dosage method of Rifampicine by HLPC
- Setting up of a plasmatic dosage method of Izoniazide by HLPC
- Setting up a dosage method of Lopinavir and Ritonavir by HLPC